|Other Names||Folate transporter 1, FOLT, Intestinal folate carrier 1, IFC-1, Placental folate transporter, Reduced folate carrier protein, RFC, Solute carrier family 19 member 1, SLC19A1, FLOT1, RFC1|
|Target/Specificity||The synthetic peptide sequence is selected from aa 206-218 of HUMAN SLC19A1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Placenta, liver, and to a much smaller extent, in lung|
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Provided below are standard protocols that you may find useful for product applications.
Transport of folate compounds into mammalian cells can occur via receptor-mediated (see MIM 136430) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Locke, A.E., et al. Genet. Epidemiol. 34(6):613-623(2010)
Adjei, A.A., et al. J Thorac Oncol 5(9):1346-1353(2010)
O'Byrne, M.R., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(8):689-694(2010)
Tsunoda, A., et al. Ann. Oncol. (2010) In press :
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