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SLC19A1 Blocking Peptide (Center)

Synthetic peptide

Product Information
Primary Accession P41440
Other Accession NP_919231.1
Additional Information
Gene ID 6573
Other Names Folate transporter 1, FOLT, Intestinal folate carrier 1, IFC-1, Placental folate transporter, Reduced folate carrier protein, RFC, Solute carrier family 19 member 1, SLC19A1, FLOT1, RFC1
Target/Specificity The synthetic peptide sequence is selected from aa 206-218 of HUMAN SLC19A1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC19A1
Synonyms FLOT1, RFC1
Function Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Placenta, liver, and to a much smaller extent, in lung
Research Areas
Citations (0)

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Transport of folate compounds into mammalian cells can occur via receptor-mediated (see MIM 136430) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Locke, A.E., et al. Genet. Epidemiol. 34(6):613-623(2010)
Adjei, A.A., et al. J Thorac Oncol 5(9):1346-1353(2010)
O'Byrne, M.R., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(8):689-694(2010)
Tsunoda, A., et al. Ann. Oncol. (2010) In press :

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$ 80.00
$ 99.00
Cat# BP20133c
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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