|Other Names||GPI mannosyltransferase 3, 241-, GPI mannosyltransferase III, GPI-MT-III, Phosphatidylinositol-glycan biosynthesis class B protein, PIG-B, PIGB|
|Target/Specificity||The synthetic peptide sequence is selected from aa 43-56 of HUMAN PIGB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Hwang, G.W., et al. J Toxicol Sci 32(5):581-583(2007)
Anikster, Y., et al. Am. J. Hum. Genet. 71(2):407-414(2002)
Kinoshita, T., et al. Curr Opin Chem Biol 4(6):632-638(2000)
Takahashi, M., et al. EMBO J. 15(16):4254-4261(1996)
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