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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Macrophage Inflammatory Protein 3 (MIP3) beta (CCL19) Antibody (N-term) Blocking peptide   

Macrophage Inflammatory Protein 3 (MIP3) beta (CCL19) Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q99731
Other Accession NP_006265
Clone Names 2112705
Additional Information
Gene ID 6363
Other Names C-C motif chemokine 19, Beta-chemokine exodus-3, CK beta-11, Epstein-Barr virus-induced molecule 1 ligand chemokine, EBI1 ligand chemokine, ELC, Macrophage inflammatory protein 3 beta, MIP-3-beta, Small-inducible cytokine A19, CCL19, ELC, MIP3B, SCYA19
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2013a was selected from the N-term region of human CCL19 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCL19
Synonyms ELC, MIP3B, SCYA19
Function May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta- arrestin (ARRB1/2) to ACKR4.
Cellular Location Secreted.
Tissue Location Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach
Research Areas
Citations (0)
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Background

The gene for CCL19 is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL19 may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.

References

Townson, J.R., et al., Eur. J. Immunol. 32(5):1230-1241 (2002).Till, K.J., et al., Blood 99(8):2977-2984 (2002).Phillips, R., et al., Eur. J. Immunol. 32(3):837-847 (2002).Ueno, T., et al., Immunity 16(2):205-218 (2002).Kim, C.H., et al., J. Immunol. 160(5):2418-2424 (1998).

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$ 277.78
Cat# BP2013a
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