|Other Names||C-C motif chemokine 19, Beta-chemokine exodus-3, CK beta-11, Epstein-Barr virus-induced molecule 1 ligand chemokine, EBI1 ligand chemokine, ELC, Macrophage inflammatory protein 3 beta, MIP-3-beta, Small-inducible cytokine A19, CCL19, ELC, MIP3B, SCYA19|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2013b was selected from the C-term region of human CCL19 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ELC, MIP3B, SCYA19|
|Function||May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.|
|Tissue Location||Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach|
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Provided below are standard protocols that you may find useful for product applications.
The gene for CCL19 is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL19 may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.
Townson, J.R., et al., Eur. J. Immunol. 32(5):1230-1241 (2002).Till, K.J., et al., Blood 99(8):2977-2984 (2002).Phillips, R., et al., Eur. J. Immunol. 32(3):837-847 (2002).Ueno, T., et al., Immunity 16(2):205-218 (2002).Kim, C.H., et al., J. Immunol. 160(5):2418-2424 (1998).
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