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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   SMAD1 Blocking Peptide (N-term)   

SMAD1 Blocking Peptide (N-term)

Synthetic peptide

Product Information
Primary Accession Q15797
Other Accession O54835, Q9JIW5, O15198, Q9R1V3, P97454, Q99717, Q9W7E7, Q56I99, P97588, P70340, Q9I8V2, Q1JQA2, NP_005891.1
Additional Information
Gene ID 4086
Other Names Mothers against decapentaplegic homolog 1, MAD homolog 1, Mothers against DPP homolog 1, JV4-1, Mad-related protein 1, SMAD family member 1, SMAD 1, Smad1, hSMAD1, Transforming growth factor-beta-signaling protein 1, BSP-1, SMAD1, BSP1, MADH1, MADR1
Target/Specificity The synthetic peptide sequence is selected from aa 14-26 of HUMAN SMAD1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMAD1
Synonyms BSP1, MADH1, MADR1
Function Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
Cellular Location Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane
Tissue Location Ubiquitous. Highest expression seen in the heart and skeletal muscle
Research Areas
Citations (0)

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The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.


Yang, J., et al. Circ. Res. 107(2):252-262(2010)
Smythies, L.E., et al. J. Biol. Chem. 285(25):19593-19604(2010)
Abhishek, K., et al. Biochem. Biophys. Res. Commun. 396(4):950-955(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Ye, F., et al. J. Exp. Clin. Cancer Res. 29, 78 (2010) :

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$ 80.00
$ 99.00
Cat# BP20141a
(40 western blots)
Availability: 2 weeks
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