|Other Names||Membrane metallo-endopeptidase-like 1, Membrane metallo-endopeptidase-like 2, NEP2(m), Neprilysin II, NEPII, Neprilysin-2, NEP2, NL2, Membrane metallo-endopeptidase-like 1, soluble form, Neprilysin-2 secreted, NEP2(s), MMEL1, MELL1, MMEL2, NEP2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 65-78 of HUMAN MMEL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||MELL1, MMEL2, NEP2|
|Function||Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity).|
|Cellular Location||Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteollytic cleavage also exists.|
|Tissue Location||Predominantly expressed in testis. Weakly expressed in brain, kidney and heart|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.
van der Helm-van Mil, A.H., et al. Ann. Rheum. Dis. 69(9):1694-1696(2010)
Hirschfield, G.M., et al. Nat. Genet. 42(8):655-657(2010)
Stahl, E.A., et al. Nat. Genet. 42(6):508-514(2010)
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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