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MMEL1 Blocking Peptide (N-term)

Synthetic peptide

Product Information
Primary Accession Q495T6
Other Accession NP_258428.2
Additional Information
Gene ID 79258
Other Names Membrane metallo-endopeptidase-like 1, Membrane metallo-endopeptidase-like 2, NEP2(m), Neprilysin II, NEPII, Neprilysin-2, NEP2, NL2, Membrane metallo-endopeptidase-like 1, soluble form, Neprilysin-2 secreted, NEP2(s), MMEL1, MELL1, MMEL2, NEP2
Target/Specificity The synthetic peptide sequence is selected from aa 65-78 of HUMAN MMEL1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMEL1
Synonyms MELL1, MMEL2, NEP2
Function Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity).
Cellular Location Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteollytic cleavage also exists.
Tissue Location Predominantly expressed in testis. Weakly expressed in brain, kidney and heart
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.


van der Helm-van Mil, A.H., et al. Ann. Rheum. Dis. 69(9):1694-1696(2010)
Hirschfield, G.M., et al. Nat. Genet. 42(8):655-657(2010)
Stahl, E.A., et al. Nat. Genet. 42(6):508-514(2010)
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :

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$ 80.00
$ 99.00
Cat# BP20146a
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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