|Other Names||Y-box-binding protein 2, Contrin, DNA-binding protein C, Dbpc, Germ cell-specific Y-box-binding protein, MSY2 homolog, YBX2, CSDA3, MSY2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 208-221 of HUMAN YBX2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery, myocardium, and skeletal muscle Undetectable in epithelial cells in respiratory, gastrointestinal, and urogenital tracts. Up-regulated in various carcinomas and germ cell tumors (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
YBX2 is a germ-cell specific member of the vertebrate Y box family of nucleic acid-binding proteins (Gu et al., 1998 [PubMed 9780336]; Tekur et al., 1999 [PubMed 10100484]).[supplied by OMIM].
Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)
Hammoud, S., et al. Fertil. Steril. 91(4):1090-1095(2009)
Deng, Y., et al. Urology 71(5):878-882(2008)
Kohno, Y., et al. Br. J. Cancer 94(5):710-716(2006)
Yoshida, T., et al. Biochim. Biophys. Acta 1759 (1-2), 80-88 (2006) :
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