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TMIGD2 Blocking Peptide (Center)

Synthetic peptide

Product Information
Primary Accession Q96BF3
Other Accession NP_653216.2
Additional Information
Gene ID 126259
Other Names Transmembrane and immunoglobulin domain-containing protein 2, CD28 homolog, Immunoglobulin and proline-rich receptor 1, IGPR-1, TMIGD2, CD28H, IGPR1
Target/Specificity The synthetic peptide sequence is selected from aa 134-147 of HUMAN TMIGD2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CD28H, IGPR1
Function Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T- cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cells of lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium of gastrointestinal, rectum, endometrial glands of the uterus, ureter, fallopian tube epithelium, colonic epithelium, small bowl epithelium, stomach epithelium, including both chief and parietal cells, trophoblastic epithelium of placenta, and pancreatic acinar cells (at protein level). Consistently expressed in veins and arteries (at protein level). Not detected in thyroid, cerebellum, cerebral cortex and thymus (at protein level). Expressed in lymphoid organs, with highest levels in thymus, spleen, peripheral blood lymphocytes and liver. In the thymus, expressed in CD4+ and CD8+ single- and double-positive cells, but not in immature CD4- and CD8- double- negative cells (at protein level). In peripheral blood mononuclear cells, highly expressed on CD56+ or CD16+ natural killer cells and CD3+ T-cells(at protein level). Not detected on B-cells(at protein level). Expressed in tonsils (at protein level)
Research Areas
Citations (0)

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The function of this protein is unknown.


Gerhard, D.S., et al. Genome Res. 14 (10B), 2121-2127 (2004) :

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$ 80.00
Cat# BP20167c
Availability: 2 weeks
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