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RBP4 Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P02753 |
|---|---|
| Other Accession | P04916, P27485, Q00724, NP_006735.2, Q28369 |
| Gene ID | 5950 |
|---|---|
| Other Names | Retinol-binding protein 4, Plasma retinol-binding protein, PRBP, RBP, Plasma retinol-binding protein(1-182), Plasma retinol-binding protein(1-181), Plasma retinol-binding protein(1-179), Plasma retinol-binding protein(1-176), RBP4 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 26-40 of HUMAN RBP4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RBP4 |
|---|---|
| Function | Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496). |
| Cellular Location | Secreted |
| Tissue Location | Detected in blood plasma and in urine (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.
References
Wang, S.N., et al. J. Formos. Med. Assoc. 109(6):422-429(2010)
Liu, X.H., et al. Zhonghua Yi Xue Za Zhi 90(18):1251-1254(2010)
Ku, Y.H., et al. J. Int. Med. Res. 38(3):782-791(2010)
Giacomozzi, C., et al. J. Endocrinol. Invest. 33(4):218-221(2010)
Nair, A.K., et al. PLoS ONE 5 (7), E11444 (2010) :
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