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PPP2CA Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession P67775
Other Accession P23696, P63331, P67777, P67776, P63330, P67774, NP_002706.1
Additional Information
Gene ID 5515
Other Names Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, Replication protein C, RP-C, PPP2CA
Target/Specificity The synthetic peptide sequence is selected from aa 103-116 of HUMAN PPP2CA
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP2CA
Function PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
Cellular Location Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGO2 (By similarity).
Research Areas
Citations (0)

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Background

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.

References

Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Jayadeva, G., et al. J. Biol. Chem. 285(39):29863-29873(2010)
Pradhan, S., et al. J. Biol. Chem. 285(38):29059-29068(2010)
Schmitz, M.H., et al. Nat. Cell Biol. 12(9):886-893(2010)
Antony, R., et al. J. Biol. Chem. 285(24):18301-18308(2010)

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$ 80.00
Cat# BP20181c
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