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RGS2 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession P41220
Other Accession NP_002914.1
Additional Information
Gene ID 5997
Other Names Regulator of G-protein signaling 2, RGS2, Cell growth-inhibiting gene 31 protein, G0/G1 switch regulatory protein 8, RGS2, G0S8
Target/Specificity The synthetic peptide sequence is selected from aa 19-32 of HUMAN RGS2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGS2
Synonyms G0S8
Function Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).
Cellular Location Isoform 1: Cell membrane Cytoplasm. Nucleus, nucleolus Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus
Tissue Location Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL)
Research Areas
Citations (0)

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Background

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)
Miyamoto-Matsubara, M., et al. Ann. N. Y. Acad. Sci. 1200, 112-119 (2010) :
Li, N.F., et al. Clin. Exp. Hypertens. 32(5):256-261(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :

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$ 80.00
Cat# BP20183a
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