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RGS2 Blocking Peptide (N-term)

Synthetic peptide

Product Information
Primary Accession P41220
Other Accession NP_002914.1
Additional Information
Gene ID 5997
Other Names Regulator of G-protein signaling 2, RGS2, Cell growth-inhibiting gene 31 protein, G0/G1 switch regulatory protein 8, RGS2, G0S8
Target/Specificity The synthetic peptide sequence is selected from aa 19-32 of HUMAN RGS2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGS2
Synonyms G0S8
Function Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
Cellular Location Isoform 1: Cell membrane. Cytoplasm. Nucleus, nucleolus Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus
Tissue Location Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL)
Research Areas
Citations (0)

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Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)
Miyamoto-Matsubara, M., et al. Ann. N. Y. Acad. Sci. 1200, 112-119 (2010) :
Li, N.F., et al. Clin. Exp. Hypertens. 32(5):256-261(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :

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$ 80.00
$ 99.00
Cat# BP20183a
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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