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MAP2 Blocking Peptide (S1539)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P11137 |
|---|---|
| Other Accession | P15146, P20357 |
| Gene ID | 4133 |
|---|---|
| Other Names | Microtubule-associated protein 2, MAP-2, MAP2 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 1533-1544 of HUMAN MAP2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MAP2 |
|---|---|
| Function | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection, dendrite {ECO:0000250|UniProtKB:P20357} |
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Provided below are standard protocols that you may find useful for product applications.
Background
MAP2 belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The exact function of this protein is still unknown. Similar proteins in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development.
References
Lauckner, J., et al., Neurobiol. Aging 24(6):767-776 (2003).
Laurine, E., et al., J. Biol. Chem. 278(32):29979-29986 (2003).
Liu, Y., et al., Adv Anat Pathol 10(2):101-106 (2003).
DeTure, M.A., et al., J. Biol. Chem. 277(38):34755-34759 (2002).
Al-Bassam, J., et al., J. Cell Biol. 157(7):1187-1196 (2002).
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