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ASCL1 (Achaete-scute homolog 1) Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P50553
Other Accession NP_004307
Clone Names 2120408
Peptide ID 2120408
Additional Information
Gene ID 429
Other Names Achaete-scute homolog 1, ASH-1, hASH1, Class A basic helix-loop-helix protein 46, bHLHa46, ASCL1, ASH1, BHLHA46, HASH1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2019b was selected from the C-term region of human Hash1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ASCL1
Synonyms ASH1, BHLHA46, HASH1
Function Transcription factor that controls transcriptional expression of its target genes by binding to the E box (5'-CANNTG- 3'). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Essential for the generation of olfactory and autonomic neurons (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)

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ACSL1, alternatively titled Hash1 or Mash1, is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. ACSL1 plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. The protein is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests it may also play a role in tumor formation.


Sriuranpong, V., et al., Mol. Cell. Biol. 22(9):3129-3139 (2002).Westerman, B.A., et al., Clin. Cancer Res. 8(4):1082-1086 (2002).Chen, H., et al., Cell Growth Differ. 8(6):677-686 (1997).Borges, M., et al., Nature 386(6627):852-855 (1997).Renault, B., et al., Genomics 30(1):81-83 (1995).

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$ 80.00
Cat# BP2019b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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