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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   CCND3 Blocking Peptide (C-term S282/T283)   

CCND3 Blocking Peptide (C-term S282/T283)

Synthetic peptide

Product Information
Primary Accession P30281
Other Accession P48961, P30282, Q3MHH5, NP_001129489.1
Additional Information
Gene ID 896
Other Names G1/S-specific cyclin-D3, CCND3
Target/Specificity The synthetic peptide sequence is selected from aa 277-288 of HUMAN CCND3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCND3
Function Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Cellular Location Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members
Research Areas
Citations (0)

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The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.


Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Kim, J., et al. Cytokine 50(1):42-49(2010)
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Gumina, M.R., et al. Cell Cycle 9(4):820-828(2010)
Radulovich, N., et al. Mol. Cancer 9, 24 (2010) :

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$ 80.00
$ 99.00
Cat# BP20204b
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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