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ATP8B3 Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O60423 |
|---|---|
| Other Accession | NP_620168.1 |
| Gene ID | 148229 |
|---|---|
| Other Names | Phospholipid-transporting ATPase IK, ATPase class I type 8B member 3, ATP8B3, ATP1K, FOS37502_2 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 71-84 of HUMAN ATP8B3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ATP8B3 (HGNC:13535) |
|---|---|
| Synonyms | ATP1K, FOS37502_2 |
| Function | P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida. |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q6UQ17}; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Isoform 3 was only detected in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene encodes the member 3 of the phospholipid-transporting ATPase 8B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
References
Scott, L.J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(18):7501-7506(2009)
Harris, M.J., et al. Biochim. Biophys. Acta 1633(2):127-131(2003)
Halleck, M.S., et al. Physiol. Genomics 1(3):139-150(1999)
Fries, A.S., et al. Lab. Anim. 12(1):1-4(1978)
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