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Nestin Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P48681
Clone Names 2112903
Additional Information
Gene ID 10763
Other Names Nestin, NES
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2020a was selected from the N-term region of human Nestin . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NES
Function Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).
Tissue Location CNS stem cells.
Research Areas
Citations (0)

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Nestin is a class VI intermediate filament protein expressed predominantly in stem cells of the neural tube but absent from virtually all differentiated CNS cells. In the CNS, nestin is downregulated upon differentiation and replaced by neurofilaments. Transient expression of nestin has been postulated as a key step committing cells to the neural differentiation pathway. Nestin expression has also been observed in pancreatic hematopoietic stem cell populations.


Yaworsky, P.J., et al., Dev. Biol. 205(2):309-321 (1999).Dahlstrand, J., et al., J. Cell. Sci. 103 (Pt 2), 589-597 (1992).

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$ 80.00
Cat# BP2020a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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