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FBXW4 Blocking Peptide (C-term)

Synthetic peptide

Product Information
Primary Accession P57775
Other Accession NP_071322.1
Additional Information
Gene ID 6468
Other Names F-box/WD repeat-containing protein 4, Dactylin, F-box and WD-40 domain-containing protein 4, FBXW4, FBW4, SHFM3
Target/Specificity The synthetic peptide sequence is selected from aa 356-370 of HUMAN FBXW4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXW4
Synonyms FBW4, SHFM3
Function Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.
Tissue Location Expressed in brain, kidney, lung and liver.
Research Areas
Citations (0)

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This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.


Everman, D.B., et al. Am. J. Med. Genet. A 140(13):1375-1383(2006)
Kano, H., et al. Hum. Genet. 118 (3-4), 477-483 (2005) :
Kang, Y.S., et al. Mol. Cells 17(3):397-403(2004)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Roscioli, T., et al. Am. J. Med. Genet. A 124A (2), 136-141 (2004) :

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$ 80.00
$ 99.00
Cat# BP20218B
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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