RNASE1 Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P07998 |
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Other Accession | NP_937878.1 |
Gene ID | 6035 |
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Other Names | Ribonuclease pancreatic, HP-RNase, RIB-1, RNase UpI-1, Ribonuclease 1, RNase 1, Ribonuclease A, RNase A, RNASE1, RIB1, RNS1 |
Target/Specificity | The synthetic peptide sequence is selected from aa 29-42 of HUMAN RNASE1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RNASE1 |
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Synonyms | RIB1, RNS1 |
Function | Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double- stranded RNA. |
Cellular Location | Secreted. |
Tissue Location | Pancreas and other tissues and body fluids (indicating it may have other physiological functions besides its role in digestion) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq].
References
D'Alessio, G. Biopolymers 91(12):989-994(2009)
Kover, K.E., et al. J. Mol. Biol. 379(5):953-965(2008)
Ueki, M., et al. Biochem. Genet. 46 (3-4), 145-153 (2008) :
Johnson, R.J., et al. Biochemistry 46(36):10308-10316(2007)
Cybulski, C., et al. Urol. Int. 79(1):44-49(2007)
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