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Mouse Sike1 Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9CPR7 |
|---|---|
| Other Accession | Q5FWT9, NP_079955.1 |
| Gene ID | 66641 |
|---|---|
| Other Names | Suppressor of IKBKE 1, Suppressor of IKK-epsilon, Sike1 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 51-63 of MOUSE Sike1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Sike1 |
|---|---|
| Function | Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF- kappa-B activation pathways (By similarity). |
| Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus-and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity).
References
Katayama, S., et al. Science 309(5740):1564-1566(2005)
Carninci, P., et al. Science 309(5740):1559-1563(2005)
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