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Neurogenin1 (NeuroG1) Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92886 |
|---|---|
| Other Accession | NP_006152 |
| Clone Names | 2120412 |
| Gene ID | 4762 |
|---|---|
| Other Names | Neurogenin-1, NGN-1, Class A basic helix-loop-helix protein 6, bHLHa6, Neurogenic basic-helix-loop-helix protein, Neurogenic differentiation factor 3, NeuroD3, NEUROG1, BHLHA6, NEUROD3, NGN, NGN1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2022b was selected from the C-term region of human NeuroG1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NEUROG1 |
|---|---|
| Synonyms | BHLHA6, NEUROD3, NGN, NGN1 |
| Function | Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Expression restricted to the embryonic nervous system |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Basic helix-loop-helix (bHLH) proteins are transcription factors involved in determining cell type during development. NeuroG1 is a bHLH protein with dual cell-fate specification roles. It functions during neurogenesis, and it has also been shown to inhibit the differentiation of neural stem cells into astrocytes. NeuroG1 promotes neurogenesis by functioning as a transcriptional activator, yet it inhibits astrocyte differentiation by compartmentalizing the CREB-binding protein transcription complex away from astrocyte differentiation genes and by inhibiting STAT transcription factors essential for gliogenesis.
References
Tamimi, R.M., et al., Genomics 40(2):355-357 (1997).McCormick, M.B., et al., Mol. Cell. Biol. 16(10):5792-5800 (1996).
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