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Neurogenin1 (NeuroG1) Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q92886
Other Accession NP_006152
Clone Names 2120412
Peptide ID 2120412
Additional Information
Gene ID 4762
Other Names Neurogenin-1, NGN-1, Class A basic helix-loop-helix protein 6, bHLHa6, Neurogenic basic-helix-loop-helix protein, Neurogenic differentiation factor 3, NeuroD3, NEUROG1, BHLHA6, NEUROD3, NGN, NGN1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2022b was selected from the C-term region of human NeuroG1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).
Cellular Location Nucleus.
Tissue Location Expression restricted to the embryonic nervous system
Research Areas
Citations (0)

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Basic helix-loop-helix (bHLH) proteins are transcription factors involved in determining cell type during development. NeuroG1 is a bHLH protein with dual cell-fate specification roles. It functions during neurogenesis, and it has also been shown to inhibit the differentiation of neural stem cells into astrocytes. NeuroG1 promotes neurogenesis by functioning as a transcriptional activator, yet it inhibits astrocyte differentiation by compartmentalizing the CREB-binding protein transcription complex away from astrocyte differentiation genes and by inhibiting STAT transcription factors essential for gliogenesis.


Tamimi, R.M., et al., Genomics 40(2):355-357 (1997).McCormick, M.B., et al., Mol. Cell. Biol. 16(10):5792-5800 (1996).

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$ 80.00
Cat# BP2022b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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