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CUL4B Blocking Peptide (Center)

Synthetic peptide

Product Information
Primary Accession Q13620
Other Accession A2A432, NP_003579.3
Additional Information
Gene ID 8450
Other Names Cullin-4B, CUL-4B, CUL4B, KIAA0695
Target/Specificity The synthetic peptide sequence is selected from aa 265-278 of HUMAN CUL4B
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CUL4B
Synonyms KIAA0695
Function Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation- induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.
Cellular Location Nucleus
Research Areas
Citations (0)

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This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].


Aggarwal, P., et al. Cancer Cell 18(4):329-340(2010)
Abbas, T., et al. Mol. Cell 40(1):9-21(2010)
Kerzendorfer, C., et al. Hum. Mol. Genet. 19(7):1324-1334(2010)
Gascoin-Lachambre, G., et al. Placenta 31(2):151-157(2010)
Badura-Stronka, M., et al. Clin. Genet. 77(2):141-144(2010)

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$ 80.00
$ 99.00
Cat# BP20232c
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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