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VAMP4 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession O75379
Other Accession O70480, Q32L97, NP_003753.2
Additional Information
Gene ID 8674
Other Names Vesicle-associated membrane protein 4, VAMP-4, VAMP4
Target/Specificity The synthetic peptide sequence is selected from aa 76-90 of HUMAN VAMP4
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name VAMP4
Function Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.
Cellular Location Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles
Research Areas
Citations (0)
citation

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Background

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport.

References

Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Sabra, M.M., et al. Mol. Genet. Metab. 85(2):133-139(2005)
Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
Hinners, I., et al. EMBO Rep. 4(12):1182-1189(2003)

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$ 277.78
Cat# BP20234c
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