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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   OPRK1 Blocking Peptide (Center)   

OPRK1 Blocking Peptide (Center)

Synthetic peptide

     
  • SPECIFICATION
  • CITATIONS
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Product Information
Primary Accession P41145
Other Accession P34975, P33534, NP_000903.2
Additional Information
Gene ID 4986
Other Names Kappa-type opioid receptor, K-OR-1, KOR-1, OPRK1, OPRK
Target/Specificity The synthetic peptide sequence is selected from aa 196-209 of HUMAN OPRK1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name OPRK1
Synonyms OPRK
Function G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in brain and placenta.
Research Areas
Citations (0)

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Background

Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

References

Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Bruijnzeel, A.W. Brain Res Rev 62(1):127-146(2009)
Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :

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$ 80.00
Cat# BP20237C
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