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GUCA1C Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95843 |
|---|---|
| Other Accession | NP_005450.3 |
| Gene ID | 9626 |
|---|---|
| Other Names | Guanylyl cyclase-activating protein 3, GCAP 3, Guanylate cyclase activator 1C, GUCA1C, GCAP3 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 186-199 of HUMAN GUCA1C |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GUCA1C |
|---|---|
| Synonyms | GCAP3 |
| Function | Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure. |
| Tissue Location | Retina. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GUCA1C stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.
References
Stephen, R., et al. J. Mol. Biol. 359(2):266-275(2006)
Imanishi, Y., et al. Eur. J. Neurosci. 15(1):63-78(2002)
Haeseleer, F., et al. J. Biol. Chem. 274(10):6526-6535(1999)
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