|Other Accession||Q4R5S4, NP_001003803.1|
|Other Names||ATP synthase subunit s, mitochondrial, ATP synthase-coupling factor B, FB, Mitochondrial ATP synthase regulatory component factor B, ATP5S, ATPW|
|Target/Specificity||The synthetic peptide sequence is selected from aa 51-64 of HUMAN ATP5S|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway (By similarity).|
|Cellular Location||Mitochondrion. Mitochondrion inner membrane|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified.
Ma, J., et al. Atherosclerosis 191(1):63-72(2007)
Cross, R.L. Nature 427(6973):407-408(2004)
Oster, G., et al. Trends Cell Biol. 13(3):114-121(2003)
Leyva, J.A., et al. Mol. Membr. Biol. 20(1):27-33(2003)
Belogrudov, G.I., et al. J. Biol. Chem. 277(8):6097-6103(2002)
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