|Other Accession||A1L3F5, Q9D486, NP_085132.1|
|Other Names||C-Maf-inducing protein, c-Mip, Truncated c-Maf-inducing protein, Tc-Mip, CMIP, KIAA1694, TCMIP|
|Target/Specificity||The synthetic peptide sequence is selected from aa 750-764 of HUMAN CMIP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.|
|Cellular Location||Nucleus. Cytoplasm. Note=Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS) (PubMed:12939343) (PubMed:15616553). Detected in nuclear and cytoplasmic compartments during MCNS relapse (PubMed:12939343) (PubMed:15616553). Expressed in cytoplasm only during MCNS remission and absent in normal patients (PubMed:12939343)|
|Tissue Location||Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver|
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Provided below are standard protocols that you may find useful for product applications.
CMIP plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Audard, V., et al. Blood 115(18):3756-3762(2010)
Kamal, M., et al. FEBS Lett. 584(3):500-506(2010)
Zhang, S.Y., et al. Sci Signal 3 (122), RA39 (2010) :
Newbury, D.F., et al. Am. J. Hum. Genet. 85(2):264-272(2009)
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