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TRUB2 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95900 |
|---|---|
| Other Accession | NP_056494.1 |
| Gene ID | 26995 |
|---|---|
| Other Names | Probable tRNA pseudouridine synthase 2, 5499-, TRUB2 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 131-144 of HUMAN TRUB2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TRUB2 {ECO:0000303|PubMed:12736709, ECO:0000312|HGNC:HGNC:17170} |
|---|---|
| Function | Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt- mRNAs) such as COXI and COXIII mt-mRNAs (PubMed:27974379, PubMed:31477916). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:33023933). |
| Cellular Location | Mitochondrion matrix Note=Localizes to mitochondrial RNA granules, platforms for post- transcriptional RNA modification and ribosome assembly |
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Provided below are standard protocols that you may find useful for product applications.
Background
Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).
References
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Zucchini, C., et al. Int. J. Mol. Med. 11(6):697-704(2003)
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