LRCH1 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y2L9 |
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Other Accession | P62046, NP_055931.1 |
Gene ID | 23143 |
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Other Names | Leucine-rich repeat and calponin homology domain-containing protein 1, Calponin homology domain-containing protein 1, Neuronal protein 81, NP81, LRCH1, CHDC1, KIAA1016 |
Target/Specificity | The synthetic peptide sequence is selected from aa 319-333 of HUMAN LRCH1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | LRCH1 |
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Synonyms | CHDC1, KIAA1016 |
Function | Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration. |
Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms.
References
Zintzaras, E., et al. Am. J. Epidemiol. 171(8):851-858(2010)
Jiang, Q., et al. J. Hum. Genet. 53(1):42-47(2008)
Ikegawa, S. Curr Opin Rheumatol 19(5):429-434(2007)
Snelling, S., et al. Rheumatology (Oxford) 46(2):250-252(2007)
Spector, T.D., et al. Arthritis Rheum. 54(2):524-532(2006)
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