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LRCH1 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q9Y2L9
Other Accession P62046, NP_055931.1
Additional Information
Gene ID 23143
Other Names Leucine-rich repeat and calponin homology domain-containing protein 1, Calponin homology domain-containing protein 1, Neuronal protein 81, NP81, LRCH1, CHDC1, KIAA1016
Target/Specificity The synthetic peptide sequence is selected from aa 319-333 of HUMAN LRCH1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRCH1
Synonyms CHDC1, KIAA1016
Function Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration.
Cellular Location Cytoplasm.
Research Areas
Citations (0)
citation

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Background

This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms.

References

Zintzaras, E., et al. Am. J. Epidemiol. 171(8):851-858(2010)
Jiang, Q., et al. J. Hum. Genet. 53(1):42-47(2008)
Ikegawa, S. Curr Opin Rheumatol 19(5):429-434(2007)
Snelling, S., et al. Rheumatology (Oxford) 46(2):250-252(2007)
Spector, T.D., et al. Arthritis Rheum. 54(2):524-532(2006)

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$ 277.78
Cat# BP20249c
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