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ANO6 Blocking Peptide (N-term)

Synthetic peptide

Product Information
Primary Accession Q4KMQ2
Other Accession NP_001020527.2
Additional Information
Gene ID 196527
Other Names Anoctamin-6, Small-conductance calcium-activated nonselective cation channel, SCAN channel, Transmembrane protein 16F, ANO6, TMEM16F
Target/Specificity The synthetic peptide sequence is selected from aa 83-96 of HUMAN ANO6
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANO6
Synonyms TMEM16F
Function Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.
Cellular Location Cell membrane; Multi-pass membrane protein Note=Shows an intracellular localization according to PubMed:22075693
Tissue Location Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer
Research Areas
Citations (0)

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May act as a calcium-activated chloride channel.


Rose, J. Phd, et al. Mol. Med. (2010) In press :
Hartzell, H.C., et al. J. Physiol. (Lond.) 587 (PT 10), 2127-2139 (2009) :
Katoh, M., et al. Int. J. Oncol. 24(5):1345-1349(2004)
Adams, M.D., et al. Nature 377 (6547 SUPPL), 3-174 (1995) :

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$ 80.00
$ 99.00
Cat# BP20252a
(40 western blots)
Availability: 2 weeks
Bulk Size
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