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SPTLC2 Blocking Peptide (Center)

Synthetic peptide

Product Information
Primary Accession O15270
Other Accession P97363, NP_004854.1
Additional Information
Gene ID 9517
Other Names Serine palmitoyltransferase 2, Long chain base biosynthesis protein 2, LCB 2, Long chain base biosynthesis protein 2a, LCB2a, Serine-palmitoyl-CoA transferase 2, SPT 2, SPTLC2, KIAA0526, LCB2
Target/Specificity The synthetic peptide sequence is selected from aa 387-401 of HUMAN SPTLC2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0526, LCB2
Function Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate.
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue Location Widely expressed.
Research Areas
Citations (0)

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This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. Alternatively spliced variants encoding different isoforms have been identified.


Rotthier, A., et al. Am. J. Hum. Genet. 87(4):513-522(2010)
Han, G., et al. Proc. Natl. Acad. Sci. U.S.A. 106(20):8186-8191(2009)
Hornemann, T., et al. Biochem. J. 405(1):157-164(2007)
Chen, M., et al. Plant Cell 18(12):3576-3593(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 80.00
$ 99.00
Cat# BP20262c
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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