|Other Accession||P97363, NP_004854.1|
|Other Names||Serine palmitoyltransferase 2, Long chain base biosynthesis protein 2, LCB 2, Long chain base biosynthesis protein 2a, LCB2a, Serine-palmitoyl-CoA transferase 2, SPT 2, SPTLC2, KIAA0526, LCB2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 387-401 of HUMAN SPTLC2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. Alternatively spliced variants encoding different isoforms have been identified.
Rotthier, A., et al. Am. J. Hum. Genet. 87(4):513-522(2010)
Han, G., et al. Proc. Natl. Acad. Sci. U.S.A. 106(20):8186-8191(2009)
Hornemann, T., et al. Biochem. J. 405(1):157-164(2007)
Chen, M., et al. Plant Cell 18(12):3576-3593(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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