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MTAP Blocking Peptide (N-term)

Synthetic peptide

Product Information
Primary Accession Q13126
Other Accession Q9CQ65, Q3MHF7, NP_002442.2
Additional Information
Gene ID 4507
Other Names S-methyl-5'-thioadenosine phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}, 24228 {ECO:0000255|HAMAP-Rule:MF_03155}, 5'-methylthioadenosine phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}, MTA phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}, MTAP {ECO:0000255|HAMAP-Rule:MF_03155}, MTAPase {ECO:0000255|HAMAP-Rule:MF_03155}, MTAP {ECO:0000255|HAMAP-Rule:MF_03155}, MSAP
Target/Specificity The synthetic peptide sequence is selected from aa 23-37 of HUMAN MTAP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MTAP {ECO:0000255|HAMAP-Rule:MF_03155}
Synonyms MSAP
Function Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates.
Cellular Location Cytoplasm. Nucleus {ECO:0000255|HAMAP- Rule:MF_03155}
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.


Newton-Bishop, J.A., et al. Cancer Epidemiol. Biomarkers Prev. 19(8):2043-2054(2010)
Yang, X.R., et al. Fam. Cancer (2010) In press :
Krasinskas, A.M., et al. Mod. Pathol. 23(4):531-538(2010)
Zhang, Q., et al. Zhonghua Liu Xing Bing Xue Za Zhi 31(1):83-86(2010)
Huang, H.Y., et al. Clin. Cancer Res. 15(22):6963-6972(2009)

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$ 80.00
Cat# BP20271a
Availability: 2 weeks
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