|Other Names||Long-chain-fatty-acid--CoA ligase 1, Acyl-CoA synthetase 1, ACS1, Long-chain acyl-CoA synthetase 1, LACS 1, Long-chain acyl-CoA synthetase 2, LACS 2, Long-chain fatty acid-CoA ligase 2, Palmitoyl-CoA ligase 1, Palmitoyl-CoA ligase 2, ACSL1, FACL1, FACL2, LACS, LACS1, LACS2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 520-533 of HUMAN ACSL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||FACL1, FACL2, LACS, LACS1, LACS2|
|Function||Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.|
|Cellular Location||Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein|
|Tissue Location||Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. [provided by RefSeq].
Phillips, C.M., et al. J. Lipid Res. 51(7):1793-1800(2010)
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Soupene, E., et al. BMC Mol. Biol. 7, 21 (2006) :
Kahn, B.B., et al. Cell Metab. 1(1):15-25(2005)
Mashek, D.G., et al. J. Lipid Res. 45(10):1958-1961(2004)
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