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SFXN1 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H9B4 |
|---|---|
| Other Accession | NP_073591.2 |
| Gene ID | 94081 |
|---|---|
| Other Names | Sideroflexin-1, Tricarboxylate carrier protein, TCC, SFXN1 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 308-321 of HUMAN SFXN1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SFXN1 (HGNC:16085) |
|---|---|
| Function | Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). May also transport other amino acids including alanine and cysteine (PubMed:30442778). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in tissues with high one-carbon metabolism activity, such as blood, liver and kidney |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Might be involved in the transport of a component required for iron utilization into or out of the mitochondria.
References
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Siculella, L., et al. FEBS Lett. 578(3):280-284(2004)
Siculella, L., et al. J. Lipid Res. 45(7):1333-1340(2004)
Giudetti, A.M., et al. J. Lipid Res. 44(11):2135-2141(2003)
Miyake, S., et al. Biochem. Biophys. Res. Commun. 295(2):463-468(2002)
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