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RECQL Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P46063 |
|---|
| Gene ID | 5965 |
|---|---|
| Other Names | ATP-dependent DNA helicase Q1, DNA helicase, RecQ-like type 1, RecQ1, DNA-dependent ATPase Q1, RecQ protein-like 1, RECQL, RECQ1, RECQL1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RECQL {ECO:0000303|PubMed:7961977} |
|---|---|
| Synonyms | RECQ1, RECQL1 |
| Function | DNA helicase that plays a role in DNA damage repair and genome stability (PubMed:7961977, PubMed:7527136, PubMed:8056767, PubMed:15886194, PubMed:35025765). Exhibits a magnesium- and ATP- dependent DNA-helicase activity that unwinds single- and double- stranded DNA in a 3'-5' direction (PubMed:7527136, PubMed:8056767, PubMed:35025765, PubMed:19151156). Full-length protein unwinds forked DNA substrates, resolves Holliday junctions, and has DNA strand annealing activity (PubMed:19151156, PubMed:25831490). Plays a role in restoring regressed replication forks (PubMed:35025765). Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions (PubMed:35025765). May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens (PubMed:7961977, PubMed:15886194). |
| Cellular Location | Nucleus |
| Tissue Location | High expression in heart, lung, skeletal muscle and kidney, low expression in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single-and double-stranded DNA in a 3'-5' direction.
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