VEGFC (VEGF3) Antibody Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P49767 |
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Clone Names | 2040501 |
Gene ID | 7424 |
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Other Names | Vascular endothelial growth factor C, VEGF-C, Flt4 ligand, Flt4-L, Vascular endothelial growth factor-related protein, VRP, VEGFC |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2042a was selected from the region of human VEGF3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | VEGFC |
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Function | Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. |
Cellular Location | Secreted. |
Tissue Location | Expressed in the spleen (PubMed:9247316, PubMed:8700872). Expressed in the lymph node, thymus, appendix and bone marrow (PubMed:9247316). Expressed in the heart, placenta, skeletal muscle, ovary and small intestine (PubMed:8700872, PubMed:8617204) Expressed in the prostate, testis and colon (PubMed:8700872) |
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Provided below are standard protocols that you may find useful for product applications.
Background
VEGF3 is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
References
Byeon, J.S., et al., J. Gastroenterol. Hepatol. 19(6):648-654 (2004).Su, J.L., et al., Cancer Res. 64(2):554-564 (2004).Yan, C., et al., World J. Gastroenterol. 10(6):783-790 (2004).Hsieh, C.Y., et al., J. Biomed. Sci. 11(2):249-259 (2004).Liu, X.E., et al., World J. Gastroenterol. 10(3):352-355 (2004).
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