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DHX9 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q08211
Other Accession Q28141
Additional Information
Gene ID 1660
Other Names ATP-dependent RNA helicase A, RHA, DEAH box protein 9, Leukophysin, LKP, Nuclear DNA helicase II, NDH II, DHX9, DDX9, LKP, NDH2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DHX9
Synonyms DDX9, LKP, NDH2
Function Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD- mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Positively regulates HIV-1 LTR-directed gene expression.
Cellular Location Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Can shuttle between nucleus and cytoplasm
Research Areas
Citations (0)

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Background

Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD-mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.

References

Lee C.-G., et al. J. Biol. Chem. 268:16822-16830(1993).
Abdelhaleem M.M., et al. J. Immunol. 156:2026-2035(1996).
Zhang S., et al. J. Biol. Chem. 272:11487-11494(1997).
Goshima N., et al. Nat. Methods 5:1011-1017(2008).
Gregory S.G., et al. Nature 441:315-321(2006).

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$ 80.00
Cat# BP20441a
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