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ECE2 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession O60344
Other Accession Q80Z60, Q10711
Additional Information
Gene ID 9718
Other Names Endothelin-converting enzyme 2, ECE-2, Methyltransferase-like region, 211-, Endothelin-converting enzyme 2 region, ECE2, KIAA0604
Target/Specificity The synthetic peptide sequence is selected from aa 566-579 of Human ECE2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ECE2
Synonyms KIAA0604
Function Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity.
Cellular Location Golgi apparatus membrane; Single-pass type II membrane protein. Cytoplasmic granule membrane; Single-pass type II membrane protein
Tissue Location Expressed in brain. Strongly down-regulated in inferior parietal lobe from Alzheimer disease patients (at protein level).
Research Areas
Citations (0)

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Background

Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.

References

Lorenzo M.-N., et al. Biochim. Biophys. Acta 1522:46-52(2001).
Funke-Kaiser H., et al. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Nagase T., et al. DNA Res. 5:31-39(1998).
Clark H.F., et al. Genome Res. 13:2265-2270(2003).
Muzny D.M., et al. Nature 440:1194-1198(2006).

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$ 80.00
Cat# BP20460c
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