|Other Names||CDCA7L;HR1; JPO2; R1; Cell division cycle-associated 7-like protein; Cell division cycle-associated 7-like protein; Protein JPO2; Cell division cycle-associated 7-like protein; Transcription factor RAM2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
Huang A., et al. Cancer Res. 65:5607-5619(2005).
Chen K., et al. J. Biol. Chem. 280:11552-11559(2005).
Cathomen T., et al. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
Ota T., et al. Nat. Genet. 36:40-45(2004).
Scherer S.W., et al. Science 300:767-772(2003).
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