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TICAM1 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q8IUC6
Additional Information
Gene ID 148022
Other Names TIR domain-containing adapter molecule 1, TICAM-1, Proline-rich, vinculin and TIR domain-containing protein B, Putative NF-kappa-B-activating protein 502H, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta, MyD88-3, TIR domain-containing adapter protein inducing IFN-beta, TICAM1, PRVTIRB, TRIF
Target/Specificity The synthetic peptide sequence is selected from aa 130-143 of Human TICAM1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TICAM1
Synonyms PRVTIRB, TRIF
Function Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
Cellular Location Cytoplasmic vesicle, autophagosome. Note=Colocalizes with UBQLN1 in the autophagosome.
Tissue Location Ubiquitously expressed but with higher levels in liver.
Research Areas
Citations (0)

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Background

Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

References

Bin L.-H., et al. J. Biol. Chem. 278:24526-24532(2003).
Yamamoto M., et al. J. Immunol. 169:6668-6672(2002).
Oshiumi H., et al. Nat. Immunol. 4:161-167(2003).
Nakajima T., et al. Immunogenetics 60:727-735(2008).
Matsuda A., et al. Oncogene 22:3307-3318(2003).

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$ 80.00
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Cat# BP20485a
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