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R Cask Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q62915
Other Accession O70589, O14936
Additional Information
Gene ID 29647
Other Names Peripheral plasma membrane protein CASK, Calcium/calmodulin-dependent serine protein kinase, Cask
Target/Specificity The synthetic peptide sequence is selected from aa 604-616 of Rat Cask
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Cask
Function Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
Cellular Location Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein
Tissue Location Expressed in the foot process layer of podocytes in the kidney glomerulus and in tubules (at protein level). Detected in brain and neurons
Research Areas
Citations (0)

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Background

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.

References

Hata Y., et al. J. Neurosci. 16:2488-2494(1996).
Butz S., et al. Cell 94:773-782(1998).
Hsueh Y.P., et al. Nature 404:298-302(2000).
Tabuchi K., et al. J. Neurosci. 22:4264-4273(2002).
Chetkovich D.M., et al. J. Neurosci. 22:6415-6425(2002).

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$ 80.00
$ 99.00
Cat# BP20487c
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