|Other Names||Interferon-induced guanylate-binding protein 2, GTP-binding protein 2, GBP-2, HuGBP-2, Guanine nucleotide-binding protein 2, GBP2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 207-220 of Human GBP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus membrane. Membrane; Lipid- anchor. Note=GBP2-GBP5 dimers localize to the Golgi apparatus.|
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Provided below are standard protocols that you may find useful for product applications.
Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product.
Cheng Y.-S.E., et al. Mol. Cell. Biol. 11:4717-4725(1991).
Schwemmle M., et al. Submitted (SEP-1991) to the EMBL/GenBank/DDBJ databases.
Bechtel S., et al. BMC Genomics 8:399-399(2007).
Ota T., et al. Nat. Genet. 36:40-45(2004).
Ebert L., et al. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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