|Other Names||Plakophilin-4, p0071, PKP4|
|Target/Specificity||The synthetic peptide sequence is selected from aa 1055-1068 of Human PKP4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.|
|Cellular Location||Cell junction, desmosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell membrane; Peripheral membrane protein. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells|
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Provided below are standard protocols that you may find useful for product applications.
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.
Hatzfeld M., et al. J. Cell Sci. 109:2767-2778(1996).
Hillier L.W., et al. Nature 434:724-731(2005).
Salomon A.R., et al. Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003).
Zhang Y., et al. Mol. Cell. Proteomics 4:1240-1250(2005).
Tao W.A., et al. Nat. Methods 2:591-598(2005).
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