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SEMA7A Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession O75326
Other Accession Q9QUR8
Additional Information
Gene ID 8482
Other Names Semaphorin-7A, CDw108, JMH blood group antigen, John-Milton-Hargen human blood group Ag, Semaphorin-K1, Sema K1, Semaphorin-L, Sema L, CD108, SEMA7A, CD108, SEMAL
Target/Specificity The synthetic peptide sequence is selected from aa 188-202 of Human SEMA7A
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEMA7A
Synonyms CD108, SEMAL
Function Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Cellular Location Cell membrane; Lipid- anchor, GPI-anchor; Extracellular side Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes
Tissue Location Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level) Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney
Research Areas
Citations (0)

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Background

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.

References

Lange C., et al. Genomics 51:340-350(1998).
Yamada A., et al. J. Immunol. 162:4094-4100(1999).
Xu X., et al. J. Biol. Chem. 273:22428-22434(1998).
Seltsam A., et al. Transfusion 47:133-146(2007).
Angelisova P., et al. Immunobiology 200:234-245(1999).

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$ 80.00
Cat# BP20540a
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