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SNAI1 Antibody (N-term R8) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O95863
Clone Names 80208133
Peptide ID 80208133
Additional Information
Gene ID 6615
Other Names Zinc finger protein SNAI1, Protein snail homolog 1, Protein sna, SNAI1, SNAH
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2054e was selected from the N-term region of human SNAI1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNAI1
Synonyms SNAH
Function Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Cellular Location Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs
Tissue Location Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.
Research Areas
Citations (0)

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The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo.


Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Deloukas, P., et al., Nature 414(6866):865-871 (2001).Batlle, E., et al., Nat. Cell Biol. 2(2):84-89 (2000).Paznekas, W.A., et al., Genomics 62(1):42-49 (1999).Twigg, S.R., et al., Hum. Genet. 105(4):320-326 (1999).

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$ 80.00
Cat# BP2054e
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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