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Mouse Tfap2a Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession P34056
Other Accession P58197, A1A4R9, Q9N0N3
Additional Information
Gene ID 21418
Other Names Transcription factor AP-2-alpha, AP2-alpha, AP-2 transcription factor, Activating enhancer-binding protein 2-alpha, Activator protein 2, AP-2, Tfap2a, Ap2tf, Tcfap2a
Target/Specificity The synthetic peptide sequence is selected from aa 154-166 of HUMAN Tfap2a
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tfap2a
Synonyms Ap2tf, Tcfap2a
Function Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.

References

Moser M.,et al.Nucleic Acids Res. 21:4844-4844(1993).
Meier P.,et al.Dev. Biol. 169:1-14(1995).
Carninci P.,et al.Science 309:1559-1563(2005).
Mitchell P.J.,et al.Genes Dev. 5:105-119(1991).
Yahata T.,et al.Genomics 80:601-613(2002).

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$ 80.00
Cat# BP20558c
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