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PDCL Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q13371
Other Accession Q63737, Q9DBX2, Q2HJA9
Additional Information
Gene ID 5082
Other Names Phosducin-like protein, PHLP, PDCL, PHLOP1, PhLP1
Target/Specificity The synthetic peptide sequence is selected from aa 2-15 of HUMAN PDCL
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDCL
Synonyms PHLOP1, PhLP1
Function Acts as a positive regulator of hedgehog signaling and regulates ciliary function. [Isoform 2]: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.
Cellular Location Cell projection, cilium {ECO:0000250|UniProtKB:Q9DBX2}
Research Areas
Citations (0)
citation

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Background

Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.

References

Lazarov M.E.,et al.Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 277.78
Cat# BP20562a
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