|Other Names||T-cell leukemia/lymphoma protein 1A, Oncogene TCL-1, Oncogene TCL1, Protein p14 TCL1, TCL1A, TCL1|
|Target/Specificity||The synthetic peptide sequence is selected from aa 52-66 of HUMAN TCL1A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.|
|Cellular Location||Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Note=Microsomal fraction|
|Tissue Location||Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation|
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Provided below are standard protocols that you may find useful for product applications.
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
Virgilio L.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:12530-12534(1994).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Fu T.-B.,et al.Cancer Res. 54:6297-6301(1994).
Laine J.,et al.Mol. Cell 6:395-407(2000).
Pekarsky Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:3028-3033(2000).
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