PSEN2(Presenilin-2 CTF subunit) Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P49810 |
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Other Accession | O88777, Q0MS45, Q61144, Q9XT96 |
Gene ID | 5664 |
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Other Names | Presenilin-2, PS-2, 3423-, AD3LP, AD5, E5-1, STM-2, Presenilin-2 NTF subunit, Presenilin-2 CTF subunit, PSEN2, AD4, PS2, PSNL2, STM2 |
Target/Specificity | The synthetic peptide sequence is selected from aa 431-445 of HUMAN PSEN2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PSEN2 |
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Synonyms | AD4, PS2, PSNL2, STM2 |
Function | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein |
Tissue Location | Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney. |
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Background
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
References
Levy-Lahad E.,et al.Science 269:973-977(1995).
Rogaev E.I.,et al.Nature 376:775-778(1995).
Li J.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:12180-12184(1995).
Levy-Lahad E.,et al.Genomics 34:198-204(1996).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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