|Other Names||MORC family CW-type zinc finger protein 2, Zinc finger CW-type coiled-coil domain protein 1, MORC2, KIAA0852, ZCWCC1|
|Target/Specificity||The synthetic peptide sequence is selected from aa 848-862 of HUMAN MORC2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). May act as a transcriptional repressor (PubMed:20225202). Down-regulates CA9 expression (PubMed:20110259).|
|Cellular Location||Nucleus. Cytoplasm, cytosol. Note=Mainly located in the nucleus|
|Tissue Location||Highly expressed in smooth muscle, pancreas and testis|
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May act as a transcriptional repressor. Down-regulates CA9 expression.
Nagase T.,et al.DNA Res. 5:355-364(1998).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Dunham I.,et al.Nature 402:489-495(1999).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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