CRX Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O43186 |
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Other Accession | O54751, Q9XSK0 |
Gene ID | 1406 |
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Other Names | Cone-rod homeobox protein, CRX, CORD2 |
Target/Specificity | The synthetic peptide sequence is selected from aa 284-297 of HUMAN CRX |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CRX |
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Synonyms | CORD2 |
Function | Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. |
Tissue Location | Retina. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.
References
Freund C.L.,et al.Cell 91:543-553(1997).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Roni V.,et al.BMC Genomics 8:42-42(2007).
Kimura A.,et al.J. Biol. Chem. 275:1152-1160(2000).
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